In 1681, English physician [[Thomas Sydenham]] classified chlorosis as a [[hysteria|hysterical disease]] affecting not only adolescent girls but also "slender and weakly women that seem [[Consumption (disease)|consumptive]]." He advocated [[iron]] as a treatment: "To the worn out or languid blood it gives a spur or fillip whereby the animal spirits which lay prostrate and sunken under their own weight are raised and excited."
[[Daniel Turner (physician)|]] in 1714 preferred to term chlorosis "the Pale or White Sickness ... since in its worst State the Complexion is rarely or ever a true Green, tho' bordering on that Hue". He went on to describe it as "an ill Habit of Body, arising either from Obstructions, particularly of the [[Menstruation|menstrual Purgation]], or from a Congestion of crude Humours in the [[Viscus|Viscera]], vitiating the Ferments of the Bowels, especially those of Concoction, and placing therein a depraved Appetite of Things directly preternatural, as ." One of his case studies was that of an 11-year-old girl who was found, on investigation, to have been eating large quantities of coal.ref
Chlorosis is briefly mentioned in [[Casanova]]'s [[Histoire de ma vie]]: "I do not know, but we have some physicians who say that chlorosis in girls is the result of that pleasure [[onanism | [onanism]]] indulged in to excess."